Cannabis and Cancer

The question of whether or not cannabis can be used to treat cancer patients has received a lot of attention lately. The alleged evidence that marijuana and cannabinoids can treat cancer is quite deceptive. Because there is so much fake scientific research available online, you should always check for reliable studies before relying on them. The potential use of cannabis and cannabinoids in the treatment of cancer will be covered in this article. So, can cannabis cure cancer? Read on to learn more!

Around the globe, the cannabis plant is grown and cultivated commercially. Generally, cannabis has many names. Some call it weed, kush, hemp, marijuana, etc.

Cannabis may help in treating nausea and vomiting. Meanwhile, based on clinical evidence, medicinal cannabis can help relieve certain symptoms of multiple sclerosis, AIDS, and other weakening conditions.

What are Cannabinoids?

Although cannabis and cannabinoids sound similar, they are not the same thing. Cannabinoids are compounds found in cannabis and other plants. Generally, cannabis has over 450 chemical compounds, which are mostly cannabinoids.

The following cannabinoids are particularly interesting to researchers:

  • Delta-9-tetrahydrocannabinol (THC) – this psychoactive substance can affect how the brain works, creating a feeling of euphoria or “high.”
  • Cannabidiol (CBD) – may relieve pain, decrease inflammation and reduce anxiety without creating psychoactive effects.

Cannabinoid Drugs

The following cannabinoid drugs are approved in the US for medicinal use:

1. Dronabinol (Marinol®/Syndros®) contains delta-9-tetrahydrocannabinol (THC). It is approved by the US Food and Drug Administration (FDA) to treat nausea and vomiting due to cancer chemotherapy and poor appetite and weight loss in AIDS patients.

2. Nabilone (Cesamet®) – this acts much like THC. It can be consumed by mouth to treat chemotherapy-induced nausea when other drugs can’t work.

Nabiximols is a cannabinoid drug still being studied in the US. This drug comprises a whole-plant extract with THC and cannabidiol (CBD) in an almost one-to-one mix. The drug is available in Canada and parts of Europe to treat cancer pain, muscle spasms, and multiple sclerosis (MS) pain.

While it’s not yet approved in the US, it’s being tested in clinical trials to determine if it can assist in some conditions.

Types of Cannabis Compounds

Cannabis users can choose from two ways to consume marijuana. Generally, the method of marijuana consumption can determine how long the effect lasts.

Inhaled marijuana: Smoked marijuana delivers THC directly into the bloodstream and quickly travels to the brain. However, the effects of cannabis smoke don’t last as long as consuming edible marijuana. This can be ideal for a quick boost or when you’re nauseous and want a fast remedy.

Edible marijuana: When the marijuana is consumed by mouth, the THC is poorly processed and may take hours to absorb fully. When the THC is absorbed, the liver processes it, which creates a second psychoactive compound. This substance acts on the brain and changes mood or consciousness, which affects the brain differently than THC.

Generally, knowing the amount of THC in foods is important because getting too much may cause overdose symptoms.

How do Cannabinoids Work Inside the Body?

In the human body, the cannabinoids we produce are called endocannabinoids. This interacts with molecules that are located in cells (cannabinoid receptors). A second form has been found in immune tissues.

These chemicals form the endocannabinoid system, and the network controls multiple body organs, including sleep memory learning, food digestion, pain control, inflammation, and immunity. Cannabinoids like THC or CBD have the same properties and can influence the function of their receptors in the brain.

How Cannabis Affects Cancer Symptoms

How does marijuana affect the symptoms of cancer patients? As mentioned, cannabis ingestion can be a relief for nausea and vomiting. Additionally, smoking cannabis may help treat neuropathic pain. Scientific research shows that people who took marijuana extracts in clinical trials needed less pain medicine.

Recently, clinical implications have reported that cannabinoids and THC may be able to kill or slow the growth of cancer cells. Various animal studies also show that some cannabinoids may reduce or slow the spread of certain types of cancer.

More studies are planned on whether cannabis and cannabinoids can be effective in cancer treatment.

So far, studies show that cannabis and cannabinoids can be safe in treating cancer, but they do not appear effective in controlling or curing the disease. Therefore, depending solely on marijuana as a cancer treatment while delaying conventional medical care may bring serious health consequences.

Can Cannabis Decrease the Chance of Cancer?

There’s no there’s proof that medical cannabis can decrease cancer risk. Some research suggests that the body can slow tumor cell growth.

One experiment included giving mice large doses of THC that were purified. The mice appeared to have less chance of developing cancer. However, this experiment isn’t sufficient to solidify that cannabis or cannabinoids can eliminate people’s people’s.

Using a highly pure THC and CBD mixture has shown the most promise in laboratory experiments. In contrast, synthetic cannabinoids like JWH-133 have shown potential in research settings.

Lab experiments examining many types of cancer, including the malignant brain, prostate, breast, lung, bladder, and pancreatic cancer, have shown surprising results.

The main takeaway, however, is that cannabinoids are not a “universal” cancer treatment because different cannabinoids seem to have distinct effects on different types of cancer.

High concentrations of THC are effective at killing cancer cells but also destroy the cells lining the blood vessels.

Cannabinoids, depending on the dose and the number of cannabinoid receptors on the cancer cells, can either promote the growth of cancer cells or have various other effects.

Cannabis as Cancer Therapy

Cancer research on cannabis usage for medical cannabis and recreational drugs has drastically changed in the last decade. Yet, studies regarding the harms and advantages of cannabis and cannabinoid use have lagged far behind the growing media advocacy and the use of these substances by the wider populace and cancer patients.

Projects and funding opportunity announcements involving cannabis have gathered support from the National Cancer Institute (NCI).

The conference aimed to highlight the state of the science surrounding cannabis, including its chemical components, such as cannabis sativa or naturally occurring cannabinoids, and cancer research utilizing cannabis.

Generally, this includes cancer epidemiology, use in cancer patients, cancer biology and prevention, and preclinical and clinical cancer symptom and treatment symptom management with cannabis as cancer therapy.

What Effect Does Cannabis Have on Relieving Cancer-related Pain?

Cannabinoids show promise in lowering cancer-related discomfort and treatment-related detrimental effects, according to the available data.

However, determining an appropriate dosage of medicinal cannabis might be difficult. A cancer patient’s patient’s regulated cannabis use may be compromised because smoking or consuming cannabis in tea typically yields a dose difficult to predict.

For this reason, scientists are investigating novel dosage strategies, such as mouth sprays, which provide a consistent and titratable dose. Cannabinoids effectively treat various cancer-related concerns; some of these are included below.

Nabilone and Dronabinol (Synthetic THC)

These two cannabinoid-based medicines have been used to treat chemotherapy-induced vomiting and nausea since the 1980s. Cannabinoids, however, are typically only used when all other options have been exhausted and are dangerous or ineffective.

The legalization of medical cannabis for palliative usage has occurred in several regions worldwide, particularly for treating cancer pain. However, determining an appropriate dosage of herbal cannabis might be difficult.

A patient’s regulated cannabis use may be compromised because marijuana smoking or consuming cannabis in tea typically yields a dose difficult to predict.

Sativex (Nabiximols)

Sativex has been the subject of a massive clinical trial in the UK to see whether or not it can treat cancer pain that does not respond to other treatments. No statistically significant change in self-reported pain levels between treatment and placebo was observed.

Clinical data is sparse, but cannabinoids may potentially treat cancer patients and weight loss (cachexia).

Both clinical trials that compared groups of cancer patients’ patients given THC, placebo, and cannabis extract failed to establish a significant change between the therapies and were halted prematurely.

Groups Exploring Cannabinoids and Cancer

The effectiveness of cannabis in preventing cancer cells remains unclear. Some studies suggest endocannabinoids may be able to reduce tumor formation. When examining mice with cannabis, the results from tests showed the rats had fewer risky cancers than those without cancer.

It is still not clear, based on scientific evidence, Cannabinoid use has been shown to reduce cancer risk among cancer patients.

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