The World’s Most Powerful Psychedelic: 5-MeO-DMT

In psychedelic circles, 5-MeO-DMT (otherwise known as the “Toad Venom”) is known as the God Molecule because of its unique ability to dissolve one’s ego and guide the journey into what can only be described as the center of the universe – a place where time, space, and the self do not exist. Unlike other psychedelics, the effects of 5-MeO are quick: a typical trip lasts just 20 minutes. The drug originates from the venom of a rare toad native to the Sonoran Desert.

5-MeO-DMT is the most powerful psychedelic in the world, it’s as simple as that. The drug’s physical and cognitive effects are the most complex and intense of any known psychedelic tryptamine. It is not known for producing the type of visionary experiences and strong visual hallucinations associated with N,N-DMT, but it is likely you will see complex geometric patterns, experience auditory hallucinations or experience a phenomenon known as a white-out: a blinding white light in the place of typical psychedelic visuals. The drug also produces heightened tactile awareness that can be very intense. These sensations can be positive and pleasurable or overwhelming, or a combination of both.

A 2019 study by Johns Hopkins researchers found that in a survey of 362 adults who took 5-MeO, approximately 80 percent of respondents reported improvements in anxiety and depression afterwards. The drug is also making its way into the mainstream. Mike Tyson has credited it with changing his life.

It’s very difficult to describe what happens on 5-MeO, so we will start by telling you what it is not. It is not recreational. It is also not pretty.

Here it from a real experience:

“The third dose feels much stronger than the first two. The first thing I sense is that I’m falling back with no control over my body. Then my entire sense of self begins to dissolve like ice in boiling water. It’s happening fast. I feel everything about who I am slipping away, and I can’t hold on. I feel like I’m dying. I’m terrified. I want it to stop. My facilitators are there, reassuring me that I’m safe. I can hear them, but I don’t believe them. I’m incredibly hot. I feel sick and like I want to vomit, but I also want to reserve all the energy I have to hold onto who I am. I’m screaming at the top of my lungs that I don’t want to die. I’m thrashing and writhing around and clutching onto anything I can, and all I want is for this feeling to end. My facilitators tell me to let go and I yell at them. I’m so angry. How dare they. How dare they tell me to let go when I’m clearly going to lose myself. What have I done? I don’t want to die when I haven’t been living the way I want to, trapped in a mind of anxiety and depression. I can’t die yet because I’ve been living all wrong.

In the weeks that follow, I notice the sound of the wind in the trees more than I used to. The sun looks brighter. I see friends for who they really are, without the anxiety I had been holding onto blurring my vision. Nothing riles me. But most impressive of all, my depression is gone. I am at peace with myself and my experiences. I have spent many days and weeks processing my journey. Terrifying as it was, it was the third dose—the one that shook me to the center of my core—that I treasure most. It taught me that even in the depths of my fear, I could find freedom.”

The pharmacology:

5-MeO-DMT is a methoxylated derivative of DMT. While most common psychedelics are believed to primarily elicit psychological effects through agonism of serotonin 5-HT2A receptors, 5-MeO-DMT shows 1000-fold greater affinity for 5-HT1A over 5-HT2A; In line with its affinity for 5-HT1A receptors, 5-MeO-DMT is extremely potent at suppressing the firing of dorsal raphe 5-HT neurons. Further, its activity in rats was attenuated with the 5-HT1A selective antagonist WAY-100635 while 5-HT2A selective antagonist volinanserin failed to demonstrate any change. Additional mechanisms of action such as inhibition of monoamine reuptake may be involved. A 2019 European study with 42 volunteers showed that a single inhalation produced sustained enhancement of satisfaction with life, and easing of anxiety, depression, and post-traumatic stress disorder (PTSD). A 2018 study demonstrated that a single dose of 5-MeO-DMT induced neurogenesis in mice.

Check out our Hero’s Dose 5-MeO-DMT and give it a shot, it is truly an experience like none other.